Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01GEB
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| Former ID |
DNC012867
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| Drug Name |
ROXINDOLE
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| Synonyms |
Roxindole; 112192-04-8; UNII-43227SMS0O; 3-(4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl)-1H-indol-5-ol; 3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butyl]-1H-indol-5-ol; CHEMBL431367; CHEBI:48558; 43227SMS0O; NCGC00025216-01; 3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indol-5-ol; DSSTox_RID_80082; DSSTox_CID_23895; DSSTox_GSID_43895; roxindol; roxindole[inn]; Roxindole [INN]; CAS-112192-04-8; roxindolum; Tocris-1559; AC1Q7AGH; GTPL52; AC1L55YV; SCHEMBL49673; DTXSID5043895; 119742-13-1 (mesylate); ZINC1548439
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| Drug Type |
Small molecular drug
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| Indication | Psychotic disorder [ICD-11: 6A20-6A25] | Phase 2 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H26N2O
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| Canonical SMILES |
C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O
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| InChI |
1S/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2
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| InChIKey |
HGEYJZMMUGWEOT-UHFFFAOYSA-N
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| CAS Number |
CAS 112192-04-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6349747, 9374254, 11114137, 14900636, 30422424, 47583771, 48329099, 49658794, 50916746, 85209757, 103266733, 103847333, 103916479, 113468488, 117617076, 124887037, 127339809, 127339810, 127339811, 128056374, 134222300, 134350072, 135141432, 135650930, 137248627, 142950049, 144204506, 162223603, 170466119, 179149560, 198986031, 223536057, 226433363
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| ChEBI ID |
CHEBI:48558
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 52). | |||
| REF 2 | Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996 Jan;276(1):41-8. | |||
| REF 3 | Indolebutylamines as selective 5-HT(1A) agonists. J Med Chem. 2004 Sep 9;47(19):4677-83. | |||
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