Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01IVE
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| Former ID |
DNC002402
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| Drug Name |
Lobeline
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| Synonyms |
lobeline; Lobelin; Inflatine; Lobeline [INN]; Lobelinum [INN-Latin]; Lobelina [INN-Spanish]; EINECS 202-012-3; BRN 0091533; AC1LEL62; ZINC56446; Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, (2R-(2alpha,6alpha(S*)))-; LS-88107
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| Drug Type |
Small molecular drug
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| Indication | Substance use disorder [ICD-11: 6C4Z] | Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C22H27NO2
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| Canonical SMILES |
CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(C3=CC=CC=C3)O
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| InChI |
1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m0/s1
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| InChIKey |
MXYUKLILVYORSK-HBMCJLEFSA-N
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| CAS Number |
CAS 90-69-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:48723
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. J Neurochem. 2013 Oct;127(2):187-98. | |||
| REF 2 | Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Curr Top Med Chem. 2011;11(9):1103-27. | |||
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