Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01OIK
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| Former ID |
DIB021227
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| Drug Name |
xamoterol
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| Synonyms |
ICI-118587
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C16H25N3O5
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| Canonical SMILES |
C1COCCN1C(=O)NCCNCC(COC2=CC=C(C=C2)O)O
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| InChI |
1S/C16H25N3O5/c20-13-1-3-15(4-2-13)24-12-14(21)11-17-5-6-18-16(22)19-7-9-23-10-8-19/h1-4,14,17,20-21H,5-12H2,(H,18,22)
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| InChIKey |
DXPOSRCHIDYWHW-UHFFFAOYSA-N
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| CAS Number |
CAS 81801-12-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13939, 5764875, 7978511, 10252742, 11466951, 11468071, 11486741, 14827117, 26751988, 46231703, 47207985, 47573382, 47646564, 47646565, 47720617, 48393937, 49699400, 50065257, 50104665, 50602287, 81065487, 85209357, 92308849, 103277522, 104171266, 104442200, 124750362, 124881833, 124881834, 125754602, 127801713, 135014177, 135651330, 137240023, 142970903, 144203855, 162168886, 163176430, 176484564, 179151043, 184547508, 203083278, 223441156, 224877570, 226445716
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| ChEBI ID |
CHEBI:10055
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-3 (ADRB3) | Target Info | Agonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Salivary secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta3 adrenergic receptor signaling pathway | ||||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 538). | |||
| REF 2 | Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists. Mol Pharmacol. 1999 Nov;56(5):875-85. | |||
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