Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01WXA
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| Former ID |
DIB021064
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| Drug Name |
TMB-8
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| Synonyms |
TMB-8; 8-(Diethylamino)octyl 3,4,5-trimethoxybenzoate; TMB 8; 57818-92-5; TM-8; 8-(N,N-Diethylamino)octyl-3,4,5-trimethoxybenzoate; 3,4,5-Trimethoxybenzoic acid, 8-(diethylamino)octyl ester; C22H37NO5; AC1L1KGS; AC1Q67GP; Lopac-861804; Lopac0_000022; BSPBio_001503; GTPL4323; CHEMBL258764; SCHEMBL2173737; CTK5A7496; DTXSID70206532; CHEBI:107633; HMS1989L05; HMS1791L05; HMS3402L05; 53464-72-5 (hydrochloride); ZINC3875139; EI-110; AKOS030559942; MCULE-5343453436; CCG-204118; NCGC00162047-03; NCGC00162047-01; NCGC00014998-06
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H37NO5
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| Canonical SMILES |
CCN(CC)CCCCCCCCOC(=O)C1=CC(=C(C(=C1)OC)OC)OC
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| InChI |
1S/C22H37NO5/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4/h16-17H,6-15H2,1-5H3
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| InChIKey |
IBQMHBGFMLHHLE-UHFFFAOYSA-N
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| CAS Number |
CAS 57818-92-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3139821, 4682454, 8153376, 11110668, 14756766, 26755645, 26755646, 29224537, 47365433, 47515555, 50064944, 50110926, 50110927, 53787761, 57322806, 80264075, 85788251, 90340968, 92309919, 99300833, 103567452, 103808264, 104309385, 117582090, 118498191, 124749388, 124879011, 124879012, 124879013, 124879014, 125715118, 128144559, 135061217, 137231118, 143545053, 162875813, 178101140, 184021159, 228306686, 241100547, 252455643
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| ChEBI ID |
CHEBI:107633
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3A receptor (HTR3A) | Target Info | Blocker (channel blocker) | [2] |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | 5HT3 type receptor mediated signaling pathway | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4323). | |||
| REF 2 | Characterization of interaction of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester with Torpedo californica nicotinic acetylcholine receptor and 5-hydroxytryptamine3 receptor. J Pharmacol Exp Ther. 1999 Jul;290(1):129-35. | |||
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