Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01XGX
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| Former ID |
DIB003724
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| Drug Name |
JTP-4819
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| Synonyms |
JTP-3399
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| Drug Type |
Small molecular drug
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| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Discontinued in Phase 2 | [1] | |
| Company |
Japan Tobacco Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H25N3O4
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| Canonical SMILES |
C1CC(N(C1)C(=O)C2CCCN2C(=O)NCC3=CC=CC=C3)C(=O)CO
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| InChI |
1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1
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| InChIKey |
ICULFJDHZQTNRB-HOTGVXAUSA-N
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| CAS Number |
CAS 162203-65-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prolyl endopeptidase (PREP) | Target Info | Modulator | [2] |
| KEGG Pathway | Renin-angiotensin system | |||
| Panther Pathway | Vasopressin synthesis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006163) | |||
| REF 2 | A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease. Behav Brain Res. 1997 Feb;83(1-2):147-51. | |||
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