Drug Information
Drug General Information | Top | |||
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Drug ID |
D01XIW
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Drug Name |
PMID29649907-Compound-22
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Drug Type |
Small molecular drug
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Company |
ALIOS BIOPHARMA, INC
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Structure |
Download2D MOL |
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Formula |
C30H26Cl2N2O4
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Canonical SMILES |
CN1C(CCC2=C1C=CC(=C2)OCC3=C(ON=C3C4=C(C=CC=C4Cl)Cl)C5CC5)C6=CC(=CC=C6)C(=O)O
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InChI |
1S/C30H26Cl2N2O4/c1-34-25(18-4-2-5-20(14-18)30(35)36)12-10-19-15-21(11-13-26(19)34)37-16-22-28(33-38-29(22)17-8-9-17)27-23(31)6-3-7-24(27)32/h2-7,11,13-15,17,25H,8-10,12,16H2,1H3,(H,35,36)
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InChIKey |
WROIATMBIYLPMI-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
KEGG Pathway | Bile secretion | |||
Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
Reactome | Recycling of bile acids and salts | |||
PPARA activates gene expression | ||||
Endogenous sterols | ||||
WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
Nuclear Receptors Meta-Pathway | ||||
Farnesoid X Receptor Pathway | ||||
Drug Induction of Bile Acid Pathway |
References | Top | |||
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REF 1 | Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. |
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