Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01ZSF
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| Former ID |
DNC009019
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| Drug Name |
GR-218231
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| Synonyms |
GR 218231; GR218231; CHEMBL131556; 175442-95-2; (+)-(2R)-1,2,3,4-Tetrahydro-6-[[(4-methoxyphenyl)sulfonyl]methyl]-N,N-dipropyl-2-naphthalenamine; (2R)-6-[(4-methoxyphenyl)sulfonylmethyl]-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine; AC1NSM1X; GR 218,231; GTPL70; SCHEMBL626977; DTXSID70415546; ZINC3824084; PDSP2_001398; PDSP1_001414; BDBM50214486; (3R)-N,N-Dipropyl-7-(4-methoxyphenylsulfonylmethyl)tetralin-3beta-amine
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C24H33NO3S
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| Canonical SMILES |
CCCN(CCC)C1CCC2=C(C1)C=CC(=C2)CS(=O)(=O)C3=CC=C(C=C3)OC
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| InChI |
1S/C24H33NO3S/c1-4-14-25(15-5-2)22-9-8-20-16-19(6-7-21(20)17-22)18-29(26,27)24-12-10-23(28-3)11-13-24/h6-7,10-13,16,22H,4-5,8-9,14-15,17-18H2,1-3H3
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| InChIKey |
HUXFXXWYIRBVJR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D3 receptor (D3R) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Dopaminergic synapse | ||||
| Reactome | Dopamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of t... Bioorg Med Chem. 2009 Jan 15;17(2):758-66. | |||
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