Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02CGC
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| Former ID |
DCL000270
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| Drug Name |
Sorbinil
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| Synonyms |
SBI; Sorbinilo; Sorbinilum; Sorbinilo [Spanish]; Sorbinilum [Latin]; CP 45634; CP-45634; Sorbinil (USAN/INN); D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione; (4S)-6-fluoro-2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolidine]-2',5'-dione; (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
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| Drug Type |
Small molecular drug
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| Indication | Diabetic cataract [ICD-11: 9B10.21; ICD-10: H28.0] | Terminated | [1], [2] | |
| Company |
Pfizer
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| Structure |
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Download2D MOL |
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| Formula |
C11H9FN2O3
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| Canonical SMILES |
C1COC2=C(C13C(=O)NC(=O)N3)C=C(C=C2)F
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| InChI |
1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
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| InChIKey |
LXANPKRCLVQAOG-NSHDSACASA-N
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| CAS Number |
CAS 68367-52-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
464383, 592669, 7890393, 7979348, 8898992, 12012698, 12016145, 15121785, 29215399, 37528353, 46504981, 46509502, 47207554, 48416546, 57401740, 74547229, 81066946, 87350465, 92098531, 103165545, 104540744, 104828809, 121360915, 128553726, 134338927, 134339157, 135009326, 137004922, 139060526, 141287583, 144205232, 160965885, 163726552, 170466611, 172919578, 175612299, 178103987, 179150924, 184547797, 198935949, 223454546, 226432735, 241120591
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| ChEBI ID |
CHEBI:102029
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aldose reductase (AKR1B1) | Target Info | Inhibitor | [3], [4] |
| BioCyc | Methylglyoxal degradation III | |||
| Acetone degradation I (to methylglyoxal) | ||||
| KEGG Pathway | Pentose and glucuronate interconversions | |||
| Fructose and mannose metabolism | ||||
| Galactose metabolism | ||||
| Glycerolipid metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Fructose and Mannose Degradation | |||
| Pyruvate Metabolism | ||||
| Pterine Biosynthesis | ||||
| Glycerolipid Metabolism | ||||
| Galactose Metabolism | ||||
| WikiPathways | Metapathway biotransformation | |||
| Polyol Pathway | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7415). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000008) | |||
| REF 3 | A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy. Diabetes. 1983 Oct;32(10):938-42. | |||
| REF 4 | Recent clinical experience with aldose reductase inhibitors. J Diabetes Complications. 1992 Jan-Mar;6(1):39-44. | |||
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