Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02DSZ
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| Former ID |
DNAP001417
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| Drug Name |
Temocapril hydrochloride
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| Synonyms |
Acecol (TN)
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| Drug Type |
Small molecular drug
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| Indication | Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99] | Approved | [1] | |
| Company |
Sankyo
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H29ClN2O5S2
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| Canonical SMILES |
CCOC(=O)C(CCC1=CC=CC=C1)NC2CSC(CN(C2=O)CC(=O)O)C3=CC=CS3.Cl
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| InChI |
1S/C23H28N2O5S2.ClH/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27;/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27);1H/t17-,18-,20-;/m0./s1
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| InChIKey |
XDDQNOKKZKHBIX-ASBZXGSUSA-N
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| CAS Number |
CAS 110221-44-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7848182, 10299418, 12014034, 14836097, 36887058, 49830338, 50125938, 57404542, 79973872, 85177334, 91748956, 92719255, 104630903, 118843683, 125001891, 126620952, 126652171, 136376497, 144206356, 152034675, 152254723, 160687099, 164234043, 164826268, 165239301, 170465944, 170539126, 174476450, 175427114, 196111929, 198940811, 210279530, 210281853, 226492861, 242601228, 252301088, 252356963, 252429416
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| ChEBI ID |
CHEBI:32190
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| SuperDrug ATC ID |
C09AA14
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Modulator | [2], [3] |
| KEGG Pathway | Renin-angiotensin system | |||
| Chagas disease (American trypanosomiasis) | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Natural products in drug discovery and development. J Nat Prod. 1997 Jan;60(1):52-60. | |||
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