Drug Information
Drug General Information | Top | |||
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Drug ID |
D02EAS
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Former ID |
DNC001412
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Drug Name |
TBC 11251 (TBC)
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Drug Type |
Small molecular drug
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Indication | Pulmonary arterial hypertension [ICD-11: BB01.0; ICD-9: 416] | Withdrawn from market | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C24H31N3O5
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Canonical SMILES |
CCOC1=C(N=CC=C1)N(C)C2CCN(CC2)CC3=CC=CC=C3.C(=CC(=O)O)C(=O)O
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InChI |
1S/C20H27N3O.C4H4O4/c1-3-24-19-10-7-13-21-20(19)22(2)18-11-14-23(15-12-18)16-17-8-5-4-6-9-17;5-3(6)1-2-4(7)8/h4-10,13,18H,3,11-12,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
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InChIKey |
ADAMULBLHXHVFN-BTJKTKAUSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Endothelin A receptor (EDNRA) | Target Info | Antagonist | [3] |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | ||||
Renin secretion | ||||
Pathways in cancer | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
Panther Pathway | Endothelin signaling pathway | |||
Pathway Interaction Database | Endothelins | |||
EGFR-dependent Endothelin signaling events | ||||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Peptide GPCRs | ||||
Endothelin Pathways | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007312) | |||
REF 3 | Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage:... Neurosurgery. 1998 Dec;43(6):1409-17; discussion 1417-8. |
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