Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02NJV
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| Former ID |
DNC004754
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| Drug Name |
Des-AA1,2,5,12,13-[D-Trp8,IAmp9]SRIF
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| Synonyms |
CHEMBL265836; Des-AA1,2,5,12,13-[D-Trp8,IAmp9]SRIF
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C67H84N12O11S2
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| Canonical SMILES |
CC(C)NCC1=CC=C(C=C1)CC2C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)CC6=CC=CC=C6)CCCCN)N)C(=O)O)CC7=CC=CC=C7)C(C)O
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| InChI |
1S/C67H84N12O11S2/c1-40(2)70-36-46-28-26-45(27-29-46)34-55-65(87)79-58(41(3)80)66(88)77-54(33-44-21-11-6-12-22-44)63(85)78-57(67(89)90)39-92-91-38-49(69)59(81)72-51(25-15-16-30-68)60(82)73-52(31-42-17-7-4-8-18-42)61(83)74-53(32-43-19-9-5-10-20-43)62(84)76-56(64(86)75-55)35-47-37-71-50-24-14-13-23-48(47)50/h4-14,17-24,26-29,37,40-41,49,51-58,70-71,80H,15-16,25,30-36,38-39,68-69H2,1-3H3,(H,72,81)(H,73,82)(H,74,83)(H,75,86)(H,76,84)(H,77,88)(H,78,85)(H,79,87)(H,89,90)/t41-,49-,51-,52-,53+,54+,55+,56+,57+,58-/m1/s1
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| InChIKey |
CRBKELXXBMEXSB-BHKHLLRWSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Somatostatin receptor type 1 (SSTR1) | Target Info | Inhibitor | [1] |
| Somatostatin receptor type 3 (SSTR3) | Target Info | Inhibitor | [1] | |
| Somatostatin receptor type 4 (SSTR4) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| cAMP signaling pathway | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Pathwhiz Pathway | Gastric Acid Production | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. | |||
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