Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02PMT
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| Former ID |
DIB010338
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| Drug Name |
Nagrestipen
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| Synonyms |
EMIP; BB-10010; ECI-301; Macrophage inflammatory protein 1a, British Biotech; Stem cell protector, British Biotech; MIP-1a, British Biotech; MIP-1 alpha derivatives (cancer), Effector
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| Indication | Bone marrow transplantation [ICD-11: QB63.6; ICD-9: 279.5, 996] | Phase 1 | [1] | |
| Company |
Vernalis plc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Macrophage inflammatory protein 1-alpha (CCL3) | Target Info | Modulator | [1] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| Toll-like receptor signaling pathway | ||||
| Salmonella infection | ||||
| Chagas disease (American trypanosomiasis) | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | IL9 Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| TWEAK Signaling Pathway | ||||
| RANKL Signaling Pathway | ||||
| TCR Signaling Pathway | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathway Interaction Database | IL12-mediated signaling events | |||
| Reactome | Chemokine receptors bind chemokines | |||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Senescence and Autophagy in Cancer | ||||
| GPCR ligand binding | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Macrophage inflammatory protein derivative ECI301 enhances the alarmin-associated abscopal benefits of tumor radiotherapy. Cancer Res. 2014 Sep 15;74(18):5070-8. | |||
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