Drug Information
Drug General Information | Top | |||
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Drug ID |
D02RCY
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Drug Name |
PMID29649907-Compound-41
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Drug Type |
Small molecular drug
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Company |
NOVARTIS AG CHIANELLI, Donatella LIU, Xiaodong MOLTENI, Valentina NELSON, John ROLAND, Jason RUCKER, Paul TULLY, David
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Structure |
Download2D MOL |
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Formula |
C28H21ClF2N4O5
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Canonical SMILES |
CN1C2=C(COC3=C2C=C(C=C3)Cl)C(=N1)C(=O)N(CC4=CC(=CC=C4)F)CC(=O)NC5=C(C=CC(=C5)C(=O)O)F
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InChI |
1S/C28H21ClF2N4O5/c1-34-26-19-11-17(29)6-8-23(19)40-14-20(26)25(33-34)27(37)35(12-15-3-2-4-18(30)9-15)13-24(36)32-22-10-16(28(38)39)5-7-21(22)31/h2-11H,12-14H2,1H3,(H,32,36)(H,38,39)
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InChIKey |
VJLVLEHRWCLRBO-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
KEGG Pathway | Bile secretion | |||
Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
Reactome | Recycling of bile acids and salts | |||
PPARA activates gene expression | ||||
Endogenous sterols | ||||
WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
Nuclear Receptors Meta-Pathway | ||||
Farnesoid X Receptor Pathway | ||||
Drug Induction of Bile Acid Pathway |
References | Top | |||
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REF 1 | Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. |
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