Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02TDV
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| Former ID |
DIB011392
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| Drug Name |
ZK-001
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| Synonyms |
Anfibatide; Declotana; Antithrombosis agent (injectable, angina), Lee's Pharmaceutical Holdings; Thrombolysin (injectable, angina), Lee's Pharmaceutical Holdings
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| Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Phase 1/2 | [1] | |
| Company |
Lee's Pharmaceutical Holdings (Hong Kong) Ltd
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet glycoprotein Ib alpha (CD42b) | Target Info | Modulator | [1] |
| KEGG Pathway | ECM-receptor interaction | |||
| Platelet activation | ||||
| Hematopoietic cell lineage | ||||
| Panther Pathway | Blood coagulation | |||
| Pathway Interaction Database | Beta2 integrin cell surface interactions | |||
| Reactome | Intrinsic Pathway of Fibrin Clot Formation | |||
| GP1b-IX-V activation signalling | ||||
| Platelet Adhesion to exposed collagen | ||||
| WikiPathways | Platelet Aggregation (Plug Formation) | |||
| Platelet Adhesion to exposed collagen | ||||
| GP1b-IX-V activation signalling | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis. Thromb Haemost. 2014 Feb;111(2):279-89. | |||
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