Drug Information
Drug General Information | Top | |||
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Drug ID |
D02VHD
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Former ID |
DIB020929
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Drug Name |
SCH51866
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Synonyms |
SCH 51866; SCH-51866
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H18F3N5O
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Canonical SMILES |
CN1C(=O)C2=C(N=C(N2)CC3=CC=C(C=C3)C(F)(F)F)N4C1=NC5C4CCC5
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InChI |
1S/C19H18F3N5O/c1-26-17(28)15-16(27-13-4-2-3-12(13)23-18(26)27)25-14(24-15)9-10-5-7-11(8-6-10)19(20,21)22/h5-8,12-13H,2-4,9H2,1H3,(H,24,25)/t12-,13+/m0/s1
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InChIKey |
JOSMPBVYYKRYLG-QWHCGFSZSA-N
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CAS Number |
CAS 167298-74-0
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Phosphodiesterase 1A (PDE1A) | Target Info | Inhibitor | [2] |
Phosphodiesterase 1B (PDE1B) | Target Info | Inhibitor | [2] | |
Phosphodiesterase 1C (PDE1C) | Target Info | Inhibitor | [2] | |
Phosphodiesterase 5A (PDE5A) | Target Info | Inhibitor | [2] | |
Phosphodiesterase 7B (PDE7B) | Target Info | Inhibitor | [3] | |
Phosphodiesterase 9 (PDE9) | Target Info | Inhibitor | [4] | |
KEGG Pathway | Purine metabolism | |||
cGMP-PKG signaling pathway | ||||
Calcium signaling pathway | ||||
Morphine addiction | ||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
Pathway Interaction Database | Regulation of Androgen receptor activity | |||
Reactome | cGMP effects | |||
G alpha (s) signalling events | ||||
WikiPathways | G Protein Signaling Pathways | |||
DAG and IP3 signaling | ||||
Opioid Signalling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5270). | |||
REF 2 | Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9. | |||
REF 3 | Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun. 2000 May 19;271(3):575-83. | |||
REF 4 | Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64. |
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