Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02WGN
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| Former ID |
DIB009180
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| Drug Name |
YM-114
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| Synonyms |
KAE-393; (R)-5-(2,3-Dihydro-1H-indol-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Nausea [ICD-11: MD90; ICD-10: R11] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H18ClN3O
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| Canonical SMILES |
C1CC2=C(CC1C(=O)N3CCC4=CC=CC=C43)NC=N2.Cl
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| InChI |
1S/C16H17N3O.ClH/c20-16(12-5-6-13-14(9-12)18-10-17-13)19-8-7-11-3-1-2-4-15(11)19;/h1-4,10,12H,5-9H2,(H,17,18);1H/t12-;/m1./s1
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| InChIKey |
GZXONPGTMHLBKQ-UTONKHPSSA-N
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| CAS Number |
CAS 153608-99-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3A receptor (HTR3A) | Target Info | Antagonist | [2], [3] |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | 5HT3 type receptor mediated signaling pathway | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002741) | |||
| REF 2 | Effect of serotonin (5-HT)3-receptor antagonists YM060, YM114 (KAE-393), ondansetron and granisetron on 5-HT4 receptors and gastric emptying in rodents. Jpn J Pharmacol. 1995 Nov;69(3):205-14. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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