Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02WSA
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| Former ID |
DNC006396
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| Drug Name |
5,7-dihydroxy-3-phenyl-3H-quinazolin-4-one
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| Synonyms |
3-arylquinazolinone, 1au; CHEMBL378572; BDBM19929
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H10N2O3
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| Canonical SMILES |
C1=CC=C(C=C1)N2C=NC3=C(C2=O)C(=CC(=C3)O)O
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| InChI |
1S/C14H10N2O3/c17-10-6-11-13(12(18)7-10)14(19)16(8-15-11)9-4-2-1-3-5-9/h1-8,17-18H
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| InChIKey |
LUBZIRZXRMLBKH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Estrogen receptor beta (ESR2) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Estrogen signaling pathway | |||
| Prolactin signaling pathway | ||||
| Pathway Interaction Database | Plasma membrane estrogen receptor signaling | |||
| Validated nuclear estrogen receptor beta network | ||||
| Validated nuclear estrogen receptor alpha network | ||||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Ovarian Infertility Genes | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators. J Med Chem. 2006 Apr 20;49(8):2440-55. | |||
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