Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02YIW
|
|||
| Former ID |
DIB018634
|
|||
| Drug Name |
5-(N,N-hexamethylene)-amiloride
|
|||
| Synonyms |
5-(N,N-Hexamethylene)amiloride; Hexamethyleneamiloride; 1428-95-1; Hexamethylene amiloride; HMA-5; HMA; C12H18ClN7O; 3-Amino-6-chloro-5-(1-homopiperidyl)-N-(diaminomethylene)pyrazinecarboxamide; N,N-HEXAMETHYLENEAMILORIDE; CHEBI:76400; 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)pyrazinecarboxamide; Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)-; 5-HMA; Spectrum_001596
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Coronavirus infection [ICD-11: 1D92; ICD-10: B34.2] | Preclinical | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C12H18ClN7O
|
|||
| Canonical SMILES |
C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N
|
|||
| InChI |
1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)
|
|||
| InChIKey |
RQQJJXVETXFINY-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 1428-95-1
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
3721421, 5244802, 8151288, 11110798, 11342050, 11362233, 11364490, 11367052, 11369614, 11372762, 11374345, 11377776, 11485593, 11487635, 11489485, 11491477, 11492438, 11495410, 14776630, 17404667, 24278246, 26612673, 26680153, 26749339, 29220993, 47291316, 47500609, 47736700, 48110661, 48334713, 50064415, 50105831, 50105832, 50107574, 53777210, 56463449, 57321027, 71822511, 79418853, 85086636, 85230925, 85788510, 90340799, 92303675, 93166515, 103128691, 103615298, 104298740, 117465724, 121360894
|
|||
| ChEBI ID |
CHEBI:76400
|
|||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. | |||
| REF 2 | Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor. Mol Pharmacol. 1998 May;53(5):916-25. | |||
| REF 3 | Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor. Mol Pharmacol. 2008 Jun;73(6):1808-15. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.