Drug Information
Drug General Information | Top | |||
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Drug ID |
D02ZSU
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Former ID |
DIB016750
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Drug Name |
NS-49
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Synonyms |
Garomefrine hydrochloride; ABT-232; PNO-49B
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Drug Type |
Small molecular drug
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Indication | Urinary incontinence [ICD-11: MF50.2; ICD-9: 788.3] | Discontinued in Phase 2 | [1], [2] | |
Company |
Nippon Shinyaku Co Ltd
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Structure |
Download2D MOL |
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Formula |
C9H13FN2O3S
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Canonical SMILES |
CS(=O)(=O)NC1=CC(=C(C=C1)F)C(CN)O
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InChI |
1S/C9H13FN2O3S/c1-16(14,15)12-6-2-3-8(10)7(4-6)9(13)5-11/h2-4,9,12-13H,5,11H2,1H3/t9-/m0/s1
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InChIKey |
XYLJNMCMDOOJRW-VIFPVBQESA-N
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CAS Number |
CAS 137431-02-8
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor alpha-1D (ADRA1D) | Target Info | Modulator | [3] |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Vascular smooth muscle contraction | ||||
Salivary secretion | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
Reactome | Adrenoceptors | |||
G alpha (q) signalling events | ||||
G alpha (12/13) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
Calcium Regulation in the Cardiac Cell | ||||
GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 481). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005693) | |||
REF 3 | Pharmacokinetics of NS-49, a phenethylamine class alpha 1A-adrenoceptor agonist. 3rd communication: metabolism in rats, rabbits, dogs and monkeys, and effects on hepatic drug-metabolizing enzyme activities in rats after repeated administration. Arzneimittelforschung. 1999 Jul;49(7):612-7. |
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