Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03JRG
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| Former ID |
DIB018015
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| Drug Name |
VU0364739
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| Synonyms |
VU 0364739
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| Drug Type |
Small molecular drug
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| Indication | Coagulation defect [ICD-11: 3B10.0; ICD-10: I80-I82] | Clinical trial | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C26H27FN4O2
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| Canonical SMILES |
C1CN(CCC12C(=O)NCN2C3=CC(=CC=C3)F)CCNC(=O)C4=CC5=CC=CC=C5C=C4
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| InChI |
1S/C26H27FN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)
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| InChIKey |
MSTXJJGAXXJCBY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phospholipase D2 (PLD2) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5287). | |||
| REF 2 | Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19. | |||
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