Drug Information
Drug General Information | Top | |||
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Drug ID |
D03JSS
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Former ID |
DIB011479
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Drug Name |
Tidembersat
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Synonyms |
SB-218842
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Drug Type |
Small molecular drug
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Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Discontinued in Phase 1 | [1] | |
Company |
SmithKline Beecham plc
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Structure |
Download2D MOL |
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Formula |
C20H19F2NO4
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Canonical SMILES |
CC(=O)C1=CC2=C(C=C1)OC(C(C2NC(=O)C3=CC(=CC(=C3)F)F)O)(C)C
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InChI |
1S/C20H19F2NO4/c1-10(24)11-4-5-16-15(8-11)17(18(25)20(2,3)27-16)23-19(26)12-6-13(21)9-14(22)7-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18+/m0/s1
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InChIKey |
NWHCDESSIHFNIJ-ZWKOTPCHSA-N
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CAS Number |
CAS 175013-73-7
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 1D receptor (HTR1D) | Target Info | Antagonist | [2] |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Serotonergic synapse | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
5HT1 type receptor mediated signaling pathway | ||||
Reactome | Serotonin receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010348) | |||
REF 2 | Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75. |
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