Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03NTJ
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| Former ID |
DAP001418
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| Drug Name |
Prolixin decanoate
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| Synonyms |
Modecate; Dapotum D; Flufenazine decanoate; Fluorophenazine decanoate; Fluphenaline decanoate; Fluphenazine decanoate; Fluphenazine depot; Moditen depot; Fluphenazine O-decanoate; Moditen-depo; Prolixin decanoate (TN); SQ 10,733; Fluphenazine decanoate (JAN/USP); Decanoic acid, 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester; Decanoic acid, 2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester; Decanoic acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester; Decanoic acid, 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester; 2-(4-(3-(2-(Trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl decanoate; 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethyl decanoate; 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20; ICD-9: 295] | Approved | [1] | |
| Therapeutic Class |
Antipsychotic Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C32H44F3N3O2S
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| Canonical SMILES |
CCCCCCCCCC(=O)OCCN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F
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| InChI |
1S/C32H44F3N3O2S/c1-2-3-4-5-6-7-8-14-31(39)40-24-23-37-21-19-36(20-22-37)17-11-18-38-27-12-9-10-13-29(27)41-30-16-15-26(25-28(30)38)32(33,34)35/h9-10,12-13,15-16,25H,2-8,11,14,17-24H2,1H3
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| InChIKey |
VIQCGTZFEYDQMR-UHFFFAOYSA-N
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| CAS Number |
CAS 5002-47-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10157, 442284, 5367841, 7847858, 8152159, 16865942, 29222523, 48416028, 49960438, 57321771, 75108673, 88771022, 103770837, 103821152, 104303368, 108136249, 117505029, 126674203, 129480527, 134223143, 134338575, 134338624, 134986213, 141522722, 142679208, 144227482, 162172916, 163134728, 175266897, 179225767, 221672973, 223671476, 223704746, 226426349, 241102944
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| ChEBI ID |
CHEBI:5124
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| ADReCS Drug ID | BADD_D00936 | |||
| SuperDrug ATC ID |
N05AB02
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Modulator | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016727. | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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