Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03VRC
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| Former ID |
DNC010492
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| Drug Name |
1-(4-Bromobenzyl)-1H-imidazole
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| Synonyms |
1-(4-bromobenzyl)-1H-imidazole; 72459-46-2; 1-(4-bromobenzyl)imidazole; 1H-Imidazole, 1-[(4-bromophenyl)methyl]-; CHEMBL211207; 1-[(4-bromophenyl)methyl]imidazole; 1H-Imidazole,1-[(4-bromophenyl)methyl]-; [(4-bromophenyl)methyl]imidazole; AC1MGP7Q; SCHEMBL707075; 1-(4Bromobenzyl)-1H-imidazole; KS-00000LSK; CTK5D6137; DTXSID20388130; MZJSYLIOMLCYIS-UHFFFAOYSA-N; MolPort-000-143-261; 1-(4bromo-benzyl)-1H-imidazole; HMS1603K13; CS-D0078; ZINC4810192; STK951803; ANW-63041; CB-660; SBB098736; BDBM50188088; AKOS002272497; RP05746
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C10H9BrN2
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| Canonical SMILES |
C1=CC(=CC=C1CN2C=CN=C2)Br
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| InChI |
1S/C10H9BrN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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| InChIKey |
MZJSYLIOMLCYIS-UHFFFAOYSA-N
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| CAS Number |
CAS 72459-46-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Steroid 11-beta-hydroxylase (CYP11B1) | Target Info | Inhibitor | [2] |
| Steroid 17-alpha-monooxygenase (S17AH) | Target Info | Inhibitor | [1] | |
| BioCyc | Superpathway of steroid hormone biosynthesis | |||
| Glucocorticoid biosynthesis | ||||
| Androgen biosynthesis | ||||
| Mineralocorticoid biosynthesis | ||||
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolic pathways | ||||
| Ovarian steroidogenesis | ||||
| Prolactin signaling pathway | ||||
| Pathwhiz Pathway | Androgen and Estrogen Metabolism | |||
| Steroidogenesis | ||||
| Reactome | Androgen biosynthesis | |||
| Glucocorticoid biosynthesis | ||||
| Endogenous sterols | ||||
| WikiPathways | Metapathway biotransformation | |||
| Steroid Biosynthesis | ||||
| Oxidation by Cytochrome P450 | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| Glucocorticoid & Mineralcorticoid Metabolism | ||||
| Prostate Cancer | ||||
| Phase 1 - Functionalization of compounds | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. | |||
| REF 2 | Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. | |||
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