Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03XOC
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| Former ID |
DAP000148
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| Drug Name |
Trilostane
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| Synonyms |
Desopan; Desopan (TN); Modrenal (TN); Vetoryl (TN); Vetoryl, Trilostane; Win-24540; Trilostane (JAN/USAN); (4alpha,5alpha,17beta)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile; 3,17beta-dihydroxy-4alpha,5-epoxy-5alpha-androst-2-ene-2-carbonitrile
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| Drug Type |
Small molecular drug
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| Indication | Cushing disease [ICD-11: 5A70; ICD-10: E24; ICD-9: 255] | Approved | [1], [2] | |
| Company |
Dechra Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H27NO3
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| Canonical SMILES |
CC12CCC3C(C1CCC2O)CCC45C3(CC(=C(C4O5)O)C#N)C
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| InChI |
1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
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| InChIKey |
KVJXBPDAXMEYOA-CXANFOAXSA-N
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| CAS Number |
CAS 13647-35-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
582970, 7848243, 9268061, 14753126, 14850960, 46507062, 48416665, 53789389, 56352900, 57408348, 77191778, 92716671, 99437135, 103770890, 113527831, 124757227, 125164031, 126591224, 126622687, 126654263, 127324070, 127324071, 127324072, 127324073, 127324074, 134337470, 134990249, 135692137, 136946482, 137005257, 143492476, 144206007, 144212723, 152103462, 152164604, 152242918, 160964442, 162170394, 163138502, 164194095, 165702349, 170465836, 175265964, 176262060, 176484985, 178103456, 179149866, 196105623, 210275073, 210280711
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| ChEBI ID |
CHEBI:32260
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| SuperDrug ATC ID |
H02CA01
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| SuperDrug CAS ID |
cas=013647353
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Estrogen receptor beta (ESR2) | Target Info | Modulator | [3] |
| KEGG Pathway | Estrogen signaling pathway | |||
| Prolactin signaling pathway | ||||
| Pathway Interaction Database | Plasma membrane estrogen receptor signaling | |||
| Validated nuclear estrogen receptor beta network | ||||
| Validated nuclear estrogen receptor alpha network | ||||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Ovarian Infertility Genes | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6850). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018719. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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