Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03YBR
|
|||
| Former ID |
DNC005870
|
|||
| Drug Name |
6-Phenylmethanesulfonyl-2H-pyridazin-3-one
|
|||
| Synonyms |
6-Phenylmethanesulfonyl-2H-pyridazin-3-one; 92016-73-4; CHEMBL199028; BDBM16611; Benzyl-Substituted Sulfonylpyridazinone, 15
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C11H10N2O3S
|
|||
| Canonical SMILES |
C1=CC=C(C=C1)CS(=O)(=O)C2=NNC(=O)C=C2
|
|||
| InChI |
1S/C11H10N2O3S/c14-10-6-7-11(13-12-10)17(15,16)8-9-4-2-1-3-5-9/h1-7H,8H2,(H,12,14)
|
|||
| InChIKey |
QUZYPEPCSQAPEU-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aldose reductase (AKR1B1) | Target Info | Inhibitor | [1] |
| BioCyc | Methylglyoxal degradation III | |||
| Acetone degradation I (to methylglyoxal) | ||||
| KEGG Pathway | Pentose and glucuronate interconversions | |||
| Fructose and mannose metabolism | ||||
| Galactose metabolism | ||||
| Glycerolipid metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Fructose and Mannose Degradation | |||
| Pyruvate Metabolism | ||||
| Pterine Biosynthesis | ||||
| Glycerolipid Metabolism | ||||
| Galactose Metabolism | ||||
| WikiPathways | Metapathway biotransformation | |||
| Polyol Pathway | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.