Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04AZE
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| Former ID |
DIB020899
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| Drug Name |
SB 204741
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| Synonyms |
SB-204741; SB-204,741
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C14H14N4OS
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| Canonical SMILES |
CC1=NSC(=C1)NC(=O)NC2=CC3=C(C=C2)N(C=C3)C
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| InChI |
1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
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| InChIKey |
USFUFHFQWXDVMH-UHFFFAOYSA-N
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| CAS Number |
CAS 152239-46-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4319791, 7980565, 9253653, 11111772, 11114048, 14775544, 17404818, 24278321, 34681248, 46500468, 47720605, 48243358, 48393924, 50104824, 50104825, 53777361, 57356145, 78571073, 85209283, 85231216, 90341465, 91722264, 92303715, 103306199, 111825035, 121360876, 124749572, 124799681, 124881389, 124881390, 124881391, 129413203, 131300009, 134224560, 135650984, 135698267, 136351091, 162223685, 163124999, 163564209, 164339477, 164759361, 178125737, 179149979, 184560789, 196399655, 204360509, 223454816, 229399889, 241182372
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| ChEBI ID |
CHEBI:140936
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2B receptor (HTR2B) | Target Info | Antagonist | [2] |
| 5-HT 2C receptor (HTR2C) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 221). | |||
| REF 2 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. | |||
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