Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04EIE
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| Former ID |
DNC009630
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| Drug Name |
N5-(1-iminopent-3-enyl)-L-ornithine
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| Synonyms |
Propenyl-L-NIO; hDDAH inhibitor, 1c; L-ENIPO; MolPort-009-019-384; JUSNBVJTFYDFKR-SGJFDWMWSA-N; BDBM235686; ZINC100017163; L-N5-(1-Imino-3-pentenyl) ornithine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H19N3O2
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| Canonical SMILES |
CCC=CC(=NCCCC(C(=O)O)N)N
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| InChI |
1S/C10H19N3O2/c1-2-3-6-9(12)13-7-4-5-8(11)10(14)15/h3,6,8H,2,4-5,7,11H2,1H3,(H2,12,13)(H,14,15)/b6-3+/t8-/m0/s1
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| InChIKey |
CIYWWIHMEYBDFA-HFSLJOEWSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nitric-oxide synthase brain (NOS1) | Target Info | Inhibitor | [1] |
| BioCyc | Citrulline-nitric oxide cycle | |||
| KEGG Pathway | Arginine and proline metabolism | |||
| Metabolic pathways | ||||
| Calcium signaling pathway | ||||
| Phagosome | ||||
| Circadian entrainment | ||||
| Long-term depression | ||||
| Salivary secretion | ||||
| Alzheimer's disease | ||||
| Amyotrophic lateral sclerosis (ALS) | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Panther Pathway | CCKR signaling map ST | |||
| Pathwhiz Pathway | Arginine and Proline Metabolism | |||
| Reactome | ROS production in response to bacteria | |||
| Nitric oxide stimulates guanylate cyclase | ||||
| WikiPathways | Monoamine Transport | |||
| Myometrial Relaxation and Contraction Pathways | ||||
| Amyotrophic lateral sclerosis (ALS) | ||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | ||||
| Spinal Cord Injury | ||||
| Alzheimers Disease | ||||
| Effects of Nitric Oxide | ||||
| Serotonin Transporter Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. | |||
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