Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04FVU
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| Former ID |
DAP000367
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| Drug Name |
Palonosetron
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| Synonyms |
Aloxi; Onicit; Palonosetron [INN]; Aloxi (TN); RS 25233-197; RS 25259-197; RS-25233-197; RS-25259-197; (S-(R*,R*))-2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
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| Drug Type |
Small molecular drug
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| Indication | Nausea [ICD-11: MD90; ICD-10: R11] | Approved | [1], [2] | |
| Therapeutic Class |
Antiemetics
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| Company |
Eisai Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H24N2O
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| Canonical SMILES |
C1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5
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| InChI |
1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1
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| InChIKey |
CPZBLNMUGSZIPR-NVXWUHKLSA-N
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| CAS Number |
CAS 135729-61-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14775945, 16060983, 23947646, 42981470, 75937434, 96024423, 114468570, 124971526, 135105908, 136326677, 137241149, 140711236, 143386614, 152107168, 152258952, 160647797, 162176794, 163366311, 175268166, 179149852, 184664917, 184812355, 187051789, 224406629, 226395862, 238388367, 241033029, 247473592, 249807123, 249867953, 251916686, 251917925, 252110261, 252355666, 252818196
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| ChEBI ID |
CHEBI:85161
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| ADReCS Drug ID | BADD_D01659 ; BADD_D01660 | |||
| SuperDrug ATC ID |
A04AA05
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3A receptor (HTR3A) | Target Info | Antagonist | [3] |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | 5HT3 type receptor mediated signaling pathway | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7486). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Management of postoperative nausea and vomiting: focus on palonosetron. Ther Clin Risk Manag. 2009 Feb;5(1):21-34. | |||
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