Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04KCT
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| Former ID |
DIB015361
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| Drug Name |
Org-21465
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| Synonyms |
SCHEMBL8751071; Org 21465
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| Drug Type |
Small molecular drug
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| Indication | Anaesthesia [ICD-11: 9A78.6; ICD-9: 338] | Discontinued in Phase 1 | [1] | |
| Company |
Organon BioSciences
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H43NO4
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| Canonical SMILES |
CC(=O)C1CCC2C1(CC(=O)C3C2CCC4C3(CC(C(C4)O)N5CCOC(C5)(C)C)C)C
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| InChI |
1S/C27H43NO4/c1-16(29)19-8-9-20-18-7-6-17-12-22(30)21(28-10-11-32-25(2,3)15-28)13-26(17,4)24(18)23(31)14-27(19,20)5/h17-22,24,30H,6-15H2,1-5H3/t17-,18-,19+,20-,21-,22-,24+,26-,27+/m0/s1
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| InChIKey |
HQEJMKVZYCQIIH-JJLPOIBOSA-N
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| CAS Number |
CAS 167946-96-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006459) | |||
| REF 2 | Computer-controlled infusion of ORG 21465, a water soluble steroid i.v. anaesthetic agent, into human volunteers. Br J Anaesth. 1997 Oct;79(4):433-9. | |||
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