Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04LTF
|
|||
| Former ID |
DNC014898
|
|||
| Drug Name |
TLN-4601
|
|||
| Synonyms |
Diazepinomicin; TLN-4601; BU-4664L; 733035-26-2; UNII-YPH994Y0RF; ECO-4601; YPH994Y0RF; 11H-Dibenzo(b,E)(1,4)diazepin-11-one, 5,10-dihydro-4,6,8-trihydroxy-10-((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-; TLN 4601; ECO 4601; CHEMBL550961; DTXSID40223539; SALVHVNECODMJP-GNUCVDFRSA-N; ZINC3938687; ECO-04601; DB12420; KB-81170
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 2 | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C28H34N2O4
|
|||
| Canonical SMILES |
CC(=CCCC(=CCCC(=CCN1C2=C(C(=CC(=C2)O)O)NC3=C(C1=O)C=CC=C3O)C)C)C
|
|||
| InChI |
1S/C28H34N2O4/c1-18(2)8-5-9-19(3)10-6-11-20(4)14-15-30-23-16-21(31)17-25(33)27(23)29-26-22(28(30)34)12-7-13-24(26)32/h7-8,10,12-14,16-17,29,31-33H,5-6,9,11,15H2,1-4H3/b19-10+,20-14+
|
|||
| InChIKey |
SALVHVNECODMJP-GNUCVDFRSA-N
|
|||
| CAS Number |
CAS 733035-26-2
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:156321
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Translocator protein (TSPO) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| HTLV-I infection | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00730262) Efficacy Study of TLN-4601 in Patients With Recurring Glioblastoma Multiforme. U.S. National Institutes of Health. | |||
| REF 2 | TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.Biochem Pharmacol.2010 Nov 15;80(10):1572-9. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.