Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04RBQ
|
|||
| Former ID |
DNC012768
|
|||
| Drug Name |
1,2,3,4-Tetrahydro-benzo[h]isoquinolin-8-ol
|
|||
| Synonyms |
CHEMBL130744; 1,2,3,4-Tetrahydro-benzo[h]isoquinolin-8-ol; BDBM50061318; 1,2,3,4-Tetrahydrobenz[h]isoquinolin-8-ol
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C13H13NO
|
|||
| Canonical SMILES |
C1CNCC2=C1C=CC3=C2C=CC(=C3)O
|
|||
| InChI |
1S/C13H13NO/c15-11-3-4-12-10(7-11)2-1-9-5-6-14-8-13(9)12/h1-4,7,14-15H,5-6,8H2
|
|||
| InChIKey |
MWWTWCVGHVVXBZ-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Integration of energy metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.