Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04ULU
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| Former ID |
DIB020037
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| Drug Name |
icilin
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| Synonyms |
Icilin; 36945-98-9; AG 3-5; 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one; Icilin(AG 3-5); UNII-CS70PZQ4QJ; ICILLIN; 2(1H)-Pyrimidinone, 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-; CS70PZQ4QJ; BRN 0700310; CHEMBL258405; 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone; AG-3-5; 1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidine-2-one; 2(1H)-Pyrimidinone,3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C16H13N3O4
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| Canonical SMILES |
C1C=C(NC(=O)N1C2=CC=CC=C2O)C3=CC(=CC=C3)[N+](=O)[O-]
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| InChI |
1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
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| InChIKey |
RCEFMOGVOYEGJN-UHFFFAOYSA-N
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| CAS Number |
CAS 36945-98-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
1240210, 3621329, 5192448, 10254648, 11111340, 11114126, 14752197, 17404989, 24277906, 24787011, 26119358, 46236694, 48094538, 48169372, 50036852, 50104889, 50104890, 53777532, 56463310, 57309620, 57349717, 57778978, 76773620, 85231095, 85787617, 89309934, 90341669, 92303991, 103123169, 103123170, 103563389, 104098764, 104917575, 113448265, 117621557, 121361218, 124749705, 124880477, 124880478, 125134295, 125334116, 129108203, 135117301, 135335475, 135650372, 135698361, 137101079, 137290080, 143156165, 162023115
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| ChEBI ID |
CHEBI:92845
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Long transient receptor potential channel 8 (TRPM8) | Target Info | Activator | [2] |
| Transformation-sensitive protein p120 (TRPA1) | Target Info | Activator | [3] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2429). | |||
| REF 2 | Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29;4(5):e5741. | |||
| REF 3 | ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29. | |||
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