Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05IHU
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| Former ID |
DIB002792
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| Drug Name |
Tetrahydrozoline
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| Synonyms |
Tyzine
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| Drug Type |
Small molecular drug
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| Indication | Ocular disease [ICD-11: N.A.] | Approved | [1] | |
| Company |
Fougera Pharmaceuticals Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H16N2
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| Canonical SMILES |
C1CC(C2=CC=CC=C2C1)C3=NCCN3
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| InChI |
1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15)
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| InChIKey |
BYJAVTDNIXVSPW-UHFFFAOYSA-N
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| CAS Number |
CAS 84-22-0
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:28674
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| ADReCS Drug ID | BADD_D02186 ; BADD_D02191 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Modulator | [1], [2] |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. Clin Toxicol (Phila). 2008 Feb;46(2):171-2. | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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