Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05IRT
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| Former ID |
DCL001074
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| Drug Name |
P276-00
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| Synonyms |
CHEMBL2312181; SCHEMBL1180418
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| Drug Type |
Small molecular drug
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| Indication | Mantle cell lymphoma [ICD-11: 2A85.5; ICD-10: C83.1] | Phase 2 | [1] | |
| Company |
Nicholas Piramal
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| Structure |
 |
Download2D MOL
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| Formula |
C21H21Cl2NO5
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| Canonical SMILES |
CN1CCC(C1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
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| InChI |
1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12-,14+;/m1./s1
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| InChIKey |
OOVTUOCTLAERQD-OJMBIDBESA-N
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| CAS Number |
CAS 920113-03-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A phase II, single-arm, open-label, multicenter study to evaluate the efficacy and safety of P276-00, a cyclin-dependent kinase inhibitor, in patients with relapsed or refractory mantle cell lymphoma. Clin Lymphoma Myeloma Leuk. 2015 Jul;15(7):392-7. | |||
| REF 2 | Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. | |||
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