Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05NWH
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| Former ID |
DIB020904
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| Drug Name |
SB 228357
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| Synonyms |
SB-228357; SB228357
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H17F4N3O2
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| Canonical SMILES |
COC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC(=CC(=C3)C4=CN=CC=C4)F)C(F)(F)F
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| InChI |
1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30)
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| InChIKey |
RRJLJKRFFRZRAF-UHFFFAOYSA-N
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| CAS Number |
CAS 181629-93-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13907, 5751310, 10299304, 11111785, 11114049, 14905408, 17405182, 36886717, 50104826, 50104827, 51495386, 53777726, 56311665, 85209888, 85231222, 85788143, 92303930, 103176772, 103985462, 104629870, 124749863, 124881414, 124881415, 124881416, 129170841, 131302946, 134222385, 135650995, 135698235, 162022790, 162247314, 164759629, 174006602, 184565829, 196402246, 206248427, 223440904, 223468628, 232703967, 241182374, 241375391, 249614017, 252369967
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| ChEBI ID |
CHEBI:8979
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Antagonist | [2] |
| 5-HT 2B receptor (HTR2B) | Target Info | Antagonist | [2] | |
| 5-HT 2C receptor (HTR2C) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Serotonin Receptor 2 and STAT3 Signaling | ||||
| SIDS Susceptibility Pathways | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 192). | |||
| REF 2 | Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34. | |||
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