Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05PYO
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| Former ID |
DIB018902
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| Drug Name |
aspirin-triggered resolvin D1
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| Synonyms |
AT-Resolvin D1; AT-RvD1
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C22H32O5
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| Canonical SMILES |
CCC=CCC(C=CC=CC=CC=CC(C(CC=CCCC(=O)O)O)O)O
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| InChI |
1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20-,21+/m1/s1
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| InChIKey |
OIWTWACQMDFHJG-BJEBZIPWSA-N
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| CAS Number |
CAS 528583-91-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:138179
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | FMLP-related receptor I (FPR2) | Target Info | Agonist | [2] |
| Transient receptor potential cation channel V3 (TRPV3) | Target Info | Blocker (channel blocker) | [3] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| Reactome | G alpha (q) signalling events | |||
| G alpha (i) signalling events | ||||
| TRP channels | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6239). | |||
| REF 2 | Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27. | |||
| REF 3 | 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92. | |||
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