Target Information

Content Navigation (  All   None )                                      
Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
Drug Property Profile of Target
Target Poor or Non Binders
Target Profiles in Patients
Target Affiliated Biological Pathways
References
Drug Binding Sites of Target  Top
Ligand Name: 2-APB Ligand Info
Structure Description Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution PDB:6OT5
Method Electron microscopy Resolution 3.60 Å Mutation Yes [12]
PDB Sequence
.
Residue
Distance (Å)
VAL408
4.997
ARG416
4.635
HIS417
2.484
LEU420
1.246
THR421
2.442
LEU422
3.235
GLU423
4.230
LEU425
4.031
HIS426
0.749
THR427
4.279
Residue
Distance (Å)
LEU429
2.021
HIS430
3.191
TRP433
3.278
ARG690
3.963
ARG693
1.993
LEU694
3.537
ARG696
3.245
ALA697
3.410
ILE700
4.916
Ligand Name: 2-(carboxymethylamino)-2-oxoacetic acid Ligand Info
Structure Description Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (229-255) PDB:6H9J
Method X-ray diffraction Resolution 1.83 Å Mutation No [13]
PDB Sequence
DIAALLIAAG
238
ADVNAHAKGA
248
FF
Residue
Distance (Å)
ASN242
4.788
Residue
Distance (Å)
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Inflammatory mediator regulation of TRP channels hsa04750 Affiliated Target
  Class: Organismal Systems => Sensory system Pathway Hierarchy

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.