Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T58496 | Target Info | |||
| Target Name | Transient receptor potential cation channel V3 (TRPV3) | ||||
| Synonyms | Vanilloid receptor-like 3; VRL-3; TrpV3 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TRPV3 | ||||
| Biochemical Class | Transient receptor potential catioin channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-APB | Ligand Info | |||||
| Structure Description | Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution | PDB:6OT5 | ||||
| Method | Electron microscopy | Resolution | 3.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
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| Ligand Name: 2-(carboxymethylamino)-2-oxoacetic acid | Ligand Info | |||||
| Structure Description | Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (229-255) | PDB:6H9J | ||||
| Method | X-ray diffraction | Resolution | 1.83 Å | Mutation | No | [2] |
| PDB Sequence |
DIAALLIAAG
238 ADVNAHAKGA248 FF
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| Ligand Name: 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human TRPV3 determined in lipid nanodisc | PDB:6UW4 | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | Yes | [3] |
| PDB Sequence |
RRLKKRIFAA
126 VSEGCVEELV136 ELLVELQELC146 RRRHDEDVPD156 FLMHKLTASD166 TGKTCLMKAL 176 LNINPNTKEI186 VRILLAFAEE196 NDILGRFINA206 EYTEEAYEGQ216 TALNIAIERR 226 QGDIAALLIA236 AGADVNAHAK246 GAFFNPKYQH256 EGFYFGETPL266 ALAACTNQPE 276 IVQLLMEHEQ286 TDITSRDSRG296 NNILHALVTV306 AEDFKTQNDF316 VKRMYDMILL 326 RSGNWELETT336 RNNDGLTPLQ346 LAAKMGKAEI356 LKYILSREIK366 EKRLRSLSRK 376 FTDWAYGPVS386 SSLYDLTNVD396 TTTDNSVLEI406 TVYNTNIDNR416 HEMLTLEPLH 426 TLLHMKWKKF436 AKHMFFLSFC446 FYFFYNITLT456 LVSYYRGWLQ483 LLGRMFVLIW 493 AMCISVKEGI503 AIFLLRSDAW521 FHFVFFIQAV531 LVILSVFLYL541 FAYKEYLACL 551 VLAMALGWAN561 MLYYTRGFQS571 MGMYSVMIQK581 VILHDVLKFL591 FVYIVFLLGF 601 GVALASLIEK611 KDCSSYGSFS626 DAVLELFKLT636 IGLGDLNIQQ646 NSKYPILFLF 656 LLITYVILTF666 VLLLNMLIAL676 MGETVENVSK686 ESERIWRLQR696 ARTILEFEKM 706 LPEWLRSRFR716 MGELDFRLCL732 RINEVKWTEW742 KTHVSFLNED752 PGP |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6OU or .6OU2 or .6OU3 or :36OU;style chemicals stick;color identity;select .A:440 or .A:443 or .A:444 or .A:447 or .A:493 or .A:496 or .A:497 or .A:500 or .A:501 or .A:522 or .A:523 or .A:526 or .A:528 or .A:532 or .A:549 or .A:550 or .A:553 or .A:564 or .A:565 or .A:570 or .A:571 or .A:572 or .A:574 or .A:590 or .A:591 or .A:594 or .A:595 or .A:596 or .A:598 or .A:599 or .A:600 or .A:603 or .A:624 or .A:625 or .A:626 or .A:627 or .A:629 or .A:630 or .A:633 or .A:636 or .A:637 or .A:703 or .A:706; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
MET440
3.739
LEU443
4.356
SER444
2.346
PHE447
4.664
TRP493
3.621
CYS496
3.667
ILE497
4.552
LYS500
2.448
GLU501
3.271
PHE522
4.271
HIS523
3.129
PHE526
3.775
ILE528
4.983
LEU532
4.499
ALA549
3.739
CYS550
3.876
LEU553
4.344
TYR564
3.701
TYR565
2.741
GLN570
4.282
SER571
3.372
MET572
3.773
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Regulatory switch at the cytoplasmic interface controls TRPV channel gating. Elife. 2019 May 9;8:e47746. | ||||
| REF 2 | Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (229-255) | ||||
| REF 3 | Gating of human TRPV3 in a lipid bilayer. Nat Struct Mol Biol. 2020 Jul;27(7):635-644. | ||||
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