Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T58496 | Target Info | |||
| Target Name | Transient receptor potential cation channel V3 (TRPV3) | ||||
| Synonyms | Vanilloid receptor-like 3; VRL-3; TrpV3 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TRPV3 | ||||
| Biochemical Class | Transient receptor potential catioin channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[NH3+])OC(=O)CCCCCCCC=CCCCCCCCC | ||||
| InChI | 1S/C39H76NO8P/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-39(42)48-37(36-47-49(43,44)46-34-33-40)35-45-38(41)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h17-18,37H,3-16,19-36,40H2,1-2H3,(H,43,44)/b18-17-/t37-/m1/s1 | ||||
| InChIKey | FHQVHHIBKUMWTI-OTMQOFQLSA-N | ||||
| PubChem Compound ID | 59834030 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6UW4 Cryo-EM structure of human TRPV3 determined in lipid nanodisc | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | Yes | [1] |
| PDB Sequence |
RRLKKRIFAA
126 VSEGCVEELV136 ELLVELQELC146 RRRHDEDVPD156 FLMHKLTASD166 TGKTCLMKAL 176 LNINPNTKEI186 VRILLAFAEE196 NDILGRFINA206 EYTEEAYEGQ216 TALNIAIERR 226 QGDIAALLIA236 AGADVNAHAK246 GAFFNPKYQH256 EGFYFGETPL266 ALAACTNQPE 276 IVQLLMEHEQ286 TDITSRDSRG296 NNILHALVTV306 AEDFKTQNDF316 VKRMYDMILL 326 RSGNWELETT336 RNNDGLTPLQ346 LAAKMGKAEI356 LKYILSREIK366 EKRLRSLSRK 376 FTDWAYGPVS386 SSLYDLTNVD396 TTTDNSVLEI406 TVYNTNIDNR416 HEMLTLEPLH 426 TLLHMKWKKF436 AKHMFFLSFC446 FYFFYNITLT456 LVSYYRGWLQ483 LLGRMFVLIW 493 AMCISVKEGI503 AIFLLRSDAW521 FHFVFFIQAV531 LVILSVFLYL541 FAYKEYLACL 551 VLAMALGWAN561 MLYYTRGFQS571 MGMYSVMIQK581 VILHDVLKFL591 FVYIVFLLGF 601 GVALASLIEK611 KDCSSYGSFS626 DAVLELFKLT636 IGLGDLNIQQ646 NSKYPILFLF 656 LLITYVILTF666 VLLLNMLIAL676 MGETVENVSK686 ESERIWRLQR696 ARTILEFEKM 706 LPEWLRSRFR716 MGELDFRLCL732 RINEVKWTEW742 KTHVSFLNED752 PGP |
|||||
|
|
MET440
3.739
LEU443
4.356
SER444
2.346
PHE447
4.664
TRP493
3.621
CYS496
3.667
ILE497
4.552
LYS500
2.448
GLU501
3.271
PHE522
4.271
HIS523
3.129
PHE526
3.775
ILE528
4.983
LEU532
4.499
ALA549
3.739
CYS550
3.876
LEU553
4.344
TYR564
3.701
TYR565
2.741
GLN570
4.282
SER571
3.372
MET572
3.773
|
|||||
| PDB ID: 6UW6 Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc | ||||||
| Method | Electron microscopy | Resolution | 3.66 Å | Mutation | Yes | [1] |
| PDB Sequence |
RRLKKRIFAA
126 VSEGCVEELV136 ELLVELQELC146 RRRHDEDVPD156 FLMHKLTASD166 TGATCLMKAL 176 LNINPNTKEI186 VRILLAFAEE196 NDILGRFINA206 EYTEEAYEGQ216 TALNIAIERR 226 QGDIAALLIA236 AGADVNAHAK246 GAFFNPKYQH256 EGFYFGETPL266 ALAACTNQPE 276 IVQLLMEHEQ286 TDITSRDSRG296 NNILHALVTV306 AEDFKTQNDF316 VKRMYDMILL 326 RSGNWELETT336 RNNDGLTPLQ346 LAAKMGKAEI356 LKYILSREIK366 EKRLRSLSRK 376 FTDWAYGPVS386 SSLYDLTNVD396 TTTDNSVLEI406 TVYNTNIDNR416 HEMLTLEPLH 426 TLLHMKWKKF436 AKHMFFLSFC446 FYFFYNITLT456 LVSYYRPRGW481 LQLLGRMFVL 491 IWAMCISVKE501 GIAIFLLRPS511 DLQSILSDAW521 FHFVFFIQAV531 LVILSVFLYL 541 FAYKEYLACL551 VLAMALGWAN561 MLYYTRGFQS571 MGMYSVMIQK581 VILHDVLKFL 591 FVYIVFLLGF601 GVALASLIEK611 CSSYGSFSDA628 VLELFKLTIG638 LGDLNIQQNS 648 KYPILFLFLL658 ITYVILTFVL668 LLNMLIALMG678 ETVENVSKES688 ERIWRLQRAR 698 TILEFEKMLP708 EWLRSRFRMG718 ELRLCLRINE736 VKWTEWKTHV746 SF |
|||||
|
|
MET440
3.759
LEU443
3.714
SER444
3.168
PHE447
4.913
TRP493
4.222
LYS500
3.391
GLU501
3.430
TRP521
4.732
PHE522
4.094
HIS523
3.304
PHE526
3.564
LEU532
4.167
GLU546
3.278
ALA549
3.824
CYS550
3.776
LEU553
3.814
ALA556
4.380
LEU557
4.158
ALA560
4.008
LEU563
4.009
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Gating of human TRPV3 in a lipid bilayer. Nat Struct Mol Biol. 2020 Jul;27(7):635-644. | ||||
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