Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06BPG
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| Former ID |
DCL000339
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| Drug Name |
Nomifensine
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| Synonyms |
Linamiphen; Nomifenison; Nomifensin; Nomifensina; Nomifensinum; Nomiphensine; Nomifensina [INN-Spanish]; Nomifensine [INN:BAN]; Nomifensine maleate(USAN); Nomifensinum [INN-Latin]; D,L-nomifensine; Nomifensine Maleate (1:1); R/S-nomifensine; (+)-Nomifensine; (+)-Nomiphensine; (+-)-1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine; (+-)-Nomifensin; (+-)-Nomifensine; (R)-1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine; 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine; 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine 2-butenedioate; 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine; 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine; 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine; 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinolin; 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline; 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline maleate (1:1); 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline; 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl; 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-(9CI)
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Withdrawn from market | [1], [2] | |
| Company |
Uihlein
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| Structure |
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Download2D MOL |
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| Formula |
C16H18N2
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| Canonical SMILES |
CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3
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| InChI |
1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3
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| InChIKey |
XXPANQJNYNUNES-UHFFFAOYSA-N
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| CAS Number |
CAS 24526-64-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
794756, 5633837, 7980164, 8152789, 10515322, 11335964, 11361203, 11363793, 11366355, 11368917, 11371885, 11374576, 11377079, 11462175, 11466136, 11467256, 11485132, 11485771, 11489364, 11490778, 11492893, 11494713, 14773981, 29223621, 46505804, 47216806, 47291175, 47662321, 47736520, 47959782, 48110479, 48110480, 48334529, 48416336, 49698941, 49986366, 49986367, 49986831, 50105261, 53789883, 57322316, 76113874, 85209909, 85321456, 85787884, 90340560, 103178786, 103919027, 104306667, 124750066
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| ChEBI ID |
CHEBI:116225
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| SuperDrug ATC ID |
N06AX04
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| SuperDrug CAS ID |
cas=024526645
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| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4792). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Pharmacologically induced, subsecond dopamine transients in the caudate-putamen of the anesthetized rat. Synapse. 2007 Jan;61(1):37-9. | |||
| REF 4 | Dopamine D2 receptors: a potential pharmacological target for nomifensine and tranylcypromine but not other antidepressant treatments. Pharmacol Biochem Behav. 1995 Aug;51(4):565-9. | |||
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