Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06CNP
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| Drug Name |
Abiraterone acetate
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| Synonyms |
CB-7630; JNJ-212082; Zytiga
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| Drug Type |
Small molecular drug
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| Indication | Prostate cancer [ICD-11: 2C82.0] | Approved | [1] | |
| Therapeutic Class |
Anticancer Agents
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| Structure |
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Download2D MOL |
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| Formula |
C26H33NO2
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| Canonical SMILES |
CC(=O)OC1CCC2(C3CCC4(C(C3CC=C2C1)CC=C4C5=CN=CC=C5)C)C
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| InChI |
1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1
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| InChIKey |
UVIQSJCZCSLXRZ-UBUQANBQSA-N
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| CAS Number |
CAS 154229-18-2
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:68639
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| ADReCS Drug ID | BADD_D00015 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Metabolic Effect | Increase activity | |||
| Description | Abiraterone can be metabolized by Akkermansia muciniphila, which results in the increase of the drug's activity. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Steroid 17-alpha-monooxygenase (S17AH) | Target Info | Modulator | [3] |
| BioCyc | Superpathway of steroid hormone biosynthesis | |||
| Glucocorticoid biosynthesis | ||||
| Androgen biosynthesis | ||||
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolic pathways | ||||
| Ovarian steroidogenesis | ||||
| Prolactin signaling pathway | ||||
| Pathwhiz Pathway | Androgen and Estrogen Metabolism | |||
| Steroidogenesis | ||||
| Reactome | Androgen biosynthesis | |||
| Glucocorticoid biosynthesis | ||||
| Endogenous sterols | ||||
| WikiPathways | Metapathway biotransformation | |||
| Steroid Biosynthesis | ||||
| Oxidation by Cytochrome P450 | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| Glucocorticoid & Mineralcorticoid Metabolism | ||||
| Prostate Cancer | ||||
| Phase 1 - Functionalization of compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients. Nat Commun. 2020 Sep 24;11(1):4822. | |||
| REF 3 | CYP17A1 inhibitors in castration-resistant prostate cancer.Steroids.2015 Mar;95:80-7. | |||
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