Drug Information
Drug General Information | Top | |||
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Drug ID |
D06HVH
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Former ID |
DIB019335
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Drug Name |
PMID22136433C20
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Synonyms |
NSC748497; NSC-748497; KH-CARB13; GTPL8156; BDBM50363167
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C17H16Cl2N4O
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Canonical SMILES |
CN1C2=C(C=CC(=C2Cl)Cl)C3=C1C(=O)NC4(C3C#N)CCNCC4
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InChI |
1S/C17H16Cl2N4O/c1-23-14-9(2-3-11(18)13(14)19)12-10(8-20)17(4-6-21-7-5-17)22-16(24)15(12)23/h2-3,10,21H,4-7H2,1H3,(H,22,24)
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InChIKey |
OWAWOKKHZNRHGV-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Calmodulin-dependent kinase II (CAMKK2) | Target Info | Inhibitor | [1] |
PIM-3 protein kinase (PIM3) | Target Info | Inhibitor | [1] | |
Protein kinase N1 (PKN1) | Target Info | Inhibitor | [1] | |
Serine/threonine-protein kinase pim-1 (PIM1) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Jak-STAT signaling pathway | |||
MicroRNAs in cancer | ||||
Acute myeloid leukemia | ||||
NetPath Pathway | IL9 Signaling Pathway | |||
IL5 Signaling Pathway | ||||
IL2 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | ||||
TCR Signaling Pathway | ||||
Pathway Interaction Database | GMCSF-mediated signaling events | |||
Validated targets of C-MYC transcriptional activation | ||||
Role of Calcineurin-dependent NFAT signaling in lymphocytes | ||||
IL5-mediated signaling events | ||||
IL3-mediated signaling events | ||||
C-MYB transcription factor network | ||||
WikiPathways | Ectoderm Differentiation | |||
Hematopoietic Stem Cell Differentiation |
References | Top | |||
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REF 1 | 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13. |
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