Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06IRE
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| Former ID |
DIB021085
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| Drug Name |
trichloroethanol
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| Synonyms |
2,2,2-TRICHLOROETHANOL; Trichloroethanol; 115-20-8; Trichlorethanol; Trichloroethyl alcohol; Ethanol, 2,2,2-trichloro-; 2,2,2-Trichloro-1-ethanol; (Hydroxymethyl)trichloromethane; 2,2,2-Trichloroethyl alcohol; 2,2,2-Trichloroethan-1-ol; C2H3Cl3O; UNII-AW835AJ62N; NSC 66407; beta-trichloroethanol; CCRIS 6763; CCl3CH2OH; EINECS 204-071-0; 2,2,2-trichloro-ethanol; 2,2,2-tris-chloroethanol; BRN 1697495; AW835AJ62N; CHEBI:28094; KPWDGTGXUYRARH-UHFFFAOYSA-N; .beta.,.beta.,.beta-Trichloroethanol; 2,2,2-Trichloroethanol, 99%; 4yas
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C2H3Cl3O
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| Canonical SMILES |
C(C(Cl)(Cl)Cl)O
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| InChI |
1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2
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| InChIKey |
KPWDGTGXUYRARH-UHFFFAOYSA-N
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| CAS Number |
CAS 115-20-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9693, 111467, 588139, 3134731, 7544284, 8144399, 8155783, 10504520, 12157173, 14709318, 15170878, 24900284, 29226971, 30952970, 33677449, 46394402, 48415142, 49968122, 57324883, 57389600, 74778195, 85090041, 87226434, 87576514, 88822997, 93617816, 103341628, 104317345, 113635236, 117618557, 125362849, 126546633, 126687820, 127280530, 127280531, 127280532, 127838658, 128131370, 128417629, 134974720, 135651278, 137004033, 142343713, 144087425, 162075472, 162124593, 162303546, 162757963, 163411210, 163849184
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| ChEBI ID |
CHEBI:28094
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3A receptor (HTR3A) | Target Info | Modulator (allosteric modulator) | [2] |
| 5-HT 3B receptor (HTR3B) | Target Info | Modulator (allosteric modulator) | [3] | |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | 5HT3 type receptor mediated signaling pathway | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | Iron uptake and transport | |||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2293). | |||
| REF 2 | Arginine 246 of the pretransmembrane domain 1 region alters 2,2,2-trichloroethanol action in the 5-hydroxytryptamine3A receptor. J Pharmacol Exp Ther. 2008 Mar;324(3):1011-8. | |||
| REF 3 | Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res. 2005 Dec 14;142(2):146-50. | |||
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