Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06NHS
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| Former ID |
DIB021091
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| Drug Name |
TROX-1
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| Synonyms |
GTPL7766; ZINC43203633; AJ-108280
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C22H16ClFN6O
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| Canonical SMILES |
CC1(C2=C(C=CC(=C2)C3=CC(=C(C=C3)F)Cl)N(C1=O)C4=NC=NN4)CC5=CN=CN=C5
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| InChI |
1S/C22H16ClFN6O/c1-22(8-13-9-25-11-26-10-13)16-6-14(15-2-4-18(24)17(23)7-15)3-5-19(16)30(20(22)31)21-27-12-28-29-21/h2-7,9-12H,8H2,1H3,(H,27,28,29)
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| InChIKey |
OABSWPUPIHULMQ-UHFFFAOYSA-N
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| CAS Number |
CAS 1141080-15-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) | Target Info | Inhibitor (gating inhibitor) | [2] |
| KEGG Pathway | MAPK signaling pathway | |||
| Calcium signaling pathway | ||||
| Synaptic vesicle cycle | ||||
| Retrograde endocannabinoid signaling | ||||
| Cholinergic synapse | ||||
| Serotonergic synapse | ||||
| GABAergic synapse | ||||
| Dopaminergic synapse | ||||
| Taste transduction | ||||
| Type II diabetes mellitus | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
| Ionotropic glutamate receptor pathway | ||||
| Metabotropic glutamate receptor group III pathway | ||||
| Metabotropic glutamate receptor group II pathway | ||||
| Thyrotropin-releasing hormone receptor signaling pathway | ||||
| Endogenous cannabinoid signaling | ||||
| GABA-B receptor II signaling | ||||
| Reactome | Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels | |||
| WikiPathways | Calcium Regulation in the Cardiac Cell | |||
| Synaptic Vesicle Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7766). | |||
| REF 2 | Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker. J Pharmacol Exp Ther. 2010 Aug;334(2):545-55. | |||
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