Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06SYS
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| Former ID |
DNC012050
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| Drug Name |
METHYLNORADRENALINE
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| Synonyms |
Methylnoradrenaline; Isoadrenaline; Nordephrine; alpha-Methylnorepinephrine; Dioxynorepinephrine; Dihydroxyphenylpropanolamine; l-alpha-Methylnorepinephrine; 6539-57-7; 1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)-; 2-Amino-1-(3,4-dihydroxyphenyl)propan-1-ol; 4-(2-amino-1-hydroxypropyl)benzene-1,2-diol; 3,4-Dihydrophenyl-1-amino-2-propanol-1; 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol; EINECS 229-452-9; CHEMBL764; CHEBI:81386
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H13NO3
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| Canonical SMILES |
CC(C(C1=CC(=C(C=C1)O)O)O)N
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| InChI |
1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3
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| InChIKey |
GEFQWZLICWMTKF-UHFFFAOYSA-N
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| CAS Number |
CAS 6539-57-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:81386
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. | |||
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