Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06ZVC
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| Former ID |
DNC007865
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| Drug Name |
WAY-181187
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| Synonyms |
WAY-181187; 554403-49-5; UNII-WXE3H7W295; WXE3H7W295; WAY-181,187; WAY 181187; SCHEMBL801436; WAY181187 HCl; GTPL3240; CHEMBL392760; BDBM21358; SAX-187; DTXSID50204011; EX-A799; MolPort-005-933-335; ZINC3816551; AKOS028111927; WAY-181187(SAX-187); KB-81479; FT-0700331; WAY181187.HCl pound WAY-181 187 pound(c); J-690323; N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine; 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD-11: 6B00-6B0Z; ICD-10: R45.0] | Discontinued in Phase 1 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H13ClN4O2S2
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=CN2S(=O)(=O)C3=C(N=C4N3C=CS4)Cl)CCN
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| InChI |
1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2
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| InChIKey |
RYBOXBBYCVOYNO-UHFFFAOYSA-N
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| CAS Number |
CAS 554403-49-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 6 receptor (HTR6) | Target Info | Modulator | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | |||
| Reactome | Serotonin receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3240). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021227) | |||
| REF 3 | Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466.Neuropsychopharmacology.2008 May;33(6):1323-35. | |||
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