Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07DQO
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| Former ID |
DNC009567
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| Drug Name |
N-(6-phenoxypyridin-3-yl)-1H-indole-3-carboxamide
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| Synonyms |
CHEMBL481289; N-(6-phenoxypyridin-3-yl)-1H-indole-3-carboxamide; SCHEMBL4239343; KBQZTNRCKHEJQM-UHFFFAOYSA-N; BDBM50251685; 1h-indole-3-carboxylic acid(6-phenoxy-pyridine-3-yl)-amide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H15N3O2
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| Canonical SMILES |
C1=CC=C(C=C1)OC2=NC=C(C=C2)NC(=O)C3=CNC4=CC=CC=C43
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| InChI |
1S/C20H15N3O2/c24-20(17-13-21-18-9-5-4-8-16(17)18)23-14-10-11-19(22-12-14)25-15-6-2-1-3-7-15/h1-13,21H,(H,23,24)
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| InChIKey |
KBQZTNRCKHEJQM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2C receptor (HTR2C) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3844-7. | |||
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