Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07EDS
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| Drug Name |
PMID29649907-Compound-29
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| Drug Type |
Small molecular drug
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| Company |
SALK INSTITUTE FOR BIOLOGICAL STUDIE
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| Structure |
 |
Download2D MOL |
||
| Formula |
C33H34F2N2O3
|
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| Canonical SMILES |
CN(C)C1=CC=C(C=C1)C2=CC(=C(C=C2)CN(C3=CC(=CC(=C3)C=CC(=O)OC)F)C(=O)C4CC5CCC4C5)F
|
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| InChI |
1S/C33H34F2N2O3/c1-36(2)28-11-9-23(10-12-28)24-7-8-26(31(35)18-24)20-37(33(39)30-17-21-4-6-25(30)14-21)29-16-22(15-27(34)19-29)5-13-32(38)40-3/h5,7-13,15-16,18-19,21,25,30H,4,6,14,17,20H2,1-3H3/b13-5+/t21-,25+,30?/m0/s1/i20D/t20?,21-,25+,30?
|
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| InChIKey |
AYPFTLSDFVNKEW-TZCKJPFISA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
| Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
| KEGG Pathway | Bile secretion | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Recycling of bile acids and salts | |||
| PPARA activates gene expression | ||||
| Endogenous sterols | ||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| Nuclear Receptors Meta-Pathway | ||||
| Farnesoid X Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. | |||
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