Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07FLB
|
|||
| Former ID |
DNC005909
|
|||
| Drug Name |
N-(tert-butoxycarbonyl)-norleucyl-glycine-nitrile
|
|||
| Synonyms |
dipeptide-derived nitrile, 13; CHEMBL383584; BDBM20092; tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]pentyl]carbamate
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C13H23N3O3
|
|||
| Canonical SMILES |
CCCCC(C(=O)NCC#N)NC(=O)OC(C)(C)C
|
|||
| InChI |
1S/C13H23N3O3/c1-5-6-7-10(11(17)15-9-8-14)16-12(18)19-13(2,3)4/h10H,5-7,9H2,1-4H3,(H,15,17)(H,16,18)/t10-/m0/s1
|
|||
| InChIKey |
KXUSXCUMFSXFIW-JTQLQIEISA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin K (CTSK) | Target Info | Inhibitor | [1] |
| Cathepsin L (CTSL) | Target Info | Inhibitor | [1] | |
| Cathepsin S (CTSS) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Lysosome | |||
| Phagosome | ||||
| Antigen processing and presentation | ||||
| Proteoglycans in cancer | ||||
| Rheumatoid arthritis | ||||
| Tuberculosis | ||||
| Osteoclast differentiation | ||||
| Toll-like receptor signaling pathway | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| RANKL Signaling Pathway | ||||
| Reactome | Endosomal/Vacuolar pathway | |||
| Collagen degradation | ||||
| Degradation of the extracellular matrix | ||||
| Trafficking and processing of endosomal TLR | ||||
| Assembly of collagen fibrils and other multimeric structures | ||||
| MHC class II antigen presentation | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
| Class I MHC mediated antigen processing & presentation | ||||
| Trafficking and processing of endosomal TLR | ||||
| RANKL/RANK Signaling Pathway | ||||
| Osteoclast Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.