Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07KMN
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| Former ID |
DNC001470
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| Drug Name |
Trimetoquinol
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| Synonyms |
Trimetoquinol; Trimethoquinol; Inolin; Trimetoquinol-hydrochloride; AQL 208; Trikvinol (triquinol) hydrochloride; l-Trimetoquinol; Trimetoquinol (VAN); Trimethoquinol (VAN); AQ-110; CCRIS 1913; Tretoquinol l-form hydrochloride; Tetroquinol; EINECS 242-423-5; NSC 288748; TRETOQUINOL HYDROCHLORIDE; (-)-Trimethoquinol; AC1L1GTS; C19H23NO5.HCl; CHEMBL542101; SCHEMBL1630263; L-1-(3,4,5-Trimethylbenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; AQL-208; 1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydroch
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H24ClNO5
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| Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)CC2C3=CC(=C(C=C3CCN2)O)O.Cl
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| InChI |
1S/C19H23NO5.ClH/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14;/h7-10,14,20-22H,4-6H2,1-3H3;1H
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| InChIKey |
UHSXRTHJCJGEKG-UHFFFAOYSA-N
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| CAS Number |
CAS 18559-63-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-3 (ADRB3) | Target Info | Agonist | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Salivary secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta3 adrenergic receptor signaling pathway | ||||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and human beta-adrenoceptor activity of 1-(3,5-diiodo-4- methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol derivatives in vitro. J Med Chem. 2000 Feb 24;43(4):591-8. | |||
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